Autoantibodies Against Oxidized LDL Do Not Predict Atherosclerotic Vascular Disease in Non–Insulin-Dependent Diabetes Mellitus
作者： Matti I.J. Uusitupa , Leo Niskanen , Jukka Luoma , Pekka Vilja , Michele Mercuri
DOI: 10.1161/01.ATV.16.10.1236
关键词: Vascular disease 、 Complication 、 Myocardial infarction 、 Diabetes mellitus 、 Internal medicine 、 Antibody 、 Stroke 、 Medicine 、 Autoantibody 、 Common carotid artery 、 Endocrinology
摘要: Accelerated atherosclerosis in diabetes has been suggested as being due to an enhanced oxidative modification of LDL. We hypothesized that the titers autoantibodies against oxidized LDL (oxLDL) may be increased patients with non–insulin-dependent mellitus (NIDDM) and they contribute various manifestations among such patients. In a 10-year follow-up study 91 newly diagnosed NIDDM 82 nondiabetic control subjects, oxLDL (expressed ratio native LDL) were measured at baseline after 10 years. Quantitative ultrasonography examine intimal-medial thickness common carotid artery (a morphological index arterial wall injury) bifurcation was performed examination. The relationship occurrence cardiovascular death, fatal nonfatal myocardial infarction, stroke, any event well to...
sci-hub.st 参考文章(46)
M J Mitchinson, D L Brown, D V Parums, Serum antibodies to oxidized low-density lipoprotein and ceroid in chronic periaortitis. Archives of Pathology & Laboratory Medicine. ,vol. 114, pp. 383- 387 ,(1990)
August Wilhelm Wahlefeld, Triglycerides Determination after Enzymatic Hydrolysis Methods of Enzymatic Analysis (Second English Edition)#R##N#Volume 4. pp. 1831- 1835 ,(1974) , 10.1016/B978-0-12-091304-6.50036-7
Franklin H. Epstein, Daniel Steinberg, Sampath Parthasarathy, Thomas E. Carew, John C. Khoo, Joseph L. Witztum, Beyond Cholesterol New England Journal of Medicine. ,vol. 320, pp. 915- 924 ,(1989) , 10.1056/NEJM198904063201407
Stefano Bianchi, Roberto Bigazzi, Giorgio Baldari, Gianpaolo Sgherri, Vito M. Campese, Diurnal Variations of Blood Pressure and Microalbuminuria in Essential Hypertension American Journal of Hypertension. ,vol. 7, pp. 23- 29 ,(1994) , 10.1093/AJH/7.1.23
T E Craven, J E Ryu, M A Espeland, F R Kahl, W M McKinney, J F Toole, M R McMahan, C J Thompson, G Heiss, J R Crouse, Evaluation of the associations between carotid artery atherosclerosis and coronary artery stenosis. A case-control study. Circulation. ,vol. 82, pp. 1230- 1242 ,(1990) , 10.1161/01.CIR.82.4.1230
W. Palinski, M. E. Rosenfeld, S. Yla-Herttuala, G. C. Gurtner, S. S. Socher, S. W. Butler, S. Parthasarathy, T. E. Carew, D. Steinberg, J. L. Witztum, Low density lipoprotein undergoes oxidative modification in vivo Proceedings of the National Academy of Sciences of the United States of America. ,vol. 86, pp. 1372- 1376 ,(1989) , 10.1073/PNAS.86.4.1372
L. K. Niskanen, M. I. Uusitupa, H. Sarlund, O. Siitonen, K. Pyorala, Five-Year Follow-Up Study on Plasma Insulin Levels in Newly Diagnosed NIDDM Patients and Nondiabetic Subjects Diabetes Care. ,vol. 13, pp. 41- 48 ,(1990) , 10.2337/DIACARE.13.1.41
M. Brownlee, Glycation products and the pathogenesis of diabetic complications. Diabetes Care. ,vol. 15, pp. 1835- 1843 ,(1992) , 10.2337/DIACARE.15.12.1835
J H Fuller, M J Shipley, G Rose, R J Jarrett, H Keen, Mortality from coronary heart disease and stroke in relation to degree of glycaemia: the Whitehall study. BMJ. ,vol. 287, pp. 867- 870 ,(1983) , 10.1136/BMJ.287.6396.867
M. Haberland, D Fong, L Cheng, Malondialdehyde-altered protein occurs in atheroma of Watanabe heritable hyperlipidemic rabbits Science. ,vol. 241, pp. 215- 218 ,(1988) , 10.1126/SCIENCE.2455346