Aluminum Promotes the Aggregation of Alzheimer′s Amyloid β-Protein in Vitro

摘要: Abstract Amyloid β-protein is the major component of senile plaques in brains Alzheimer′s disease and has an intrinsic tendency to form insoluble aggregates. The aggregation amyloid been suggested enhance its neurotoxicity play a key role deposition. Here we show, using gel-electrophoresis immunoblotting, that synthetic (β1-40) promoted by aluminum, suspected risk factor disease. High molecular weight aggregates were observed, amount precipitated protein was estimated high performance liquid chromatography. results suggest possibility aluminum directly influences process deposition plaques.