In utero diethylstilbestrol (DES) exposure alters Hox gene expression in the developing müllerian system

作者: Karen Block , Andrew Kardana , Peter Igarashi , Hugh S. Taylor

DOI: 10.1096/FASEBJ.14.9.1101

关键词: DiethylstilbestrolRetinoic acidBiologyHomeoboxHox geneGeneGene expressionCell biologyHomeotic geneIn uteroEndocrinologyInternal medicine

摘要: Diethylstilbestrol (DES) was widely used to treat pregnant women through 1971. The reproductive tracts of their female offspring exposed to DES in utero are characterized by anatomic …

参考文章(35)
Alan H. Decherney, Ina Cholst, Frederick Naftolin, Structure and function of the fallopian tubes following exposure to diethylstilbestrol (DES) during gestation Fertility and Sterility. ,vol. 36, pp. 741- 745 ,(1981) , 10.1016/S0015-0282(16)45919-4
Thomas A. Mably, Donald L. Bjerke, Robert W. Moore, Annette Gendron-Fitzpatrick, Richard E. Peterson, In utero and lactational exposure of male rats to 2,3,7,8-tetrachlorodibenzo-p-dioxin Toxicology and Applied Pharmacology. ,vol. 114, pp. 118- 126 ,(1992) , 10.1016/0041-008X(92)90103-Y
John A. McLachlan, Retha R. Newbold, Bill C. Bullock, Long-term effects on the female mouse genital tract associated with prenatal exposure to diethylstilbestrol Cancer Research. ,vol. 40, pp. 3988- 3999 ,(1980)
W J Gradishar, V C Jordan, Clinical potential of new antiestrogens. Journal of Clinical Oncology. ,vol. 15, pp. 840- 852 ,(1997) , 10.1200/JCO.1997.15.2.840
W. Branford, K. Small, D.P. Witte, S.S. Potter, H.M. Hsieh-Li, H. Li, M. Weinstein, Hoxa 11 structure, extensive antisense transcription, and function in male and female fertility Development. ,vol. 121, pp. 1373- 1385 ,(1995) , 10.1242/DEV.121.5.1373
Miguel Beato, Peter Herrlich, Günther Schütz, Steroid hormone receptors: Many Actors in search of a plot Cell. ,vol. 83, pp. 851- 857 ,(1995) , 10.1016/0092-8674(95)90201-5
Douglas P. Mortlock, Jeffrey W. Innis, Mutation of HOXA13 in hand-foot-genital syndrome Nature Genetics. ,vol. 15, pp. 179- 180 ,(1997) , 10.1038/NG0297-179
Heather Marshall, Stefan Nonchev, Mai Har Sham, Ian Muchamore, Andrew Lumsden, Robb Krumlauf, Retinoic acid alters hindbrain Hox code and induces transformation of rhombomeres 2/3 into a 4/5 identity. Nature. ,vol. 360, pp. 737- 741 ,(1992) , 10.1038/360737A0
Mai Har Sham, Christine Vesque, Stefan Nonchev, Heather Marshall, Monique Frain, Romita Das Gupta, Jenny Whiting, David Wilkinson, Patrick Charnay, Robb Krumlauf, The zinc finger gene Krox20 regulates HoxB2 (Hox2.8) during hindbrain segmentation Cell. ,vol. 72, pp. 183- 196 ,(1993) , 10.1016/0092-8674(93)90659-E