Memory T Cells and Their Costimulators in Human Allograft Injury
作者： Stephen L. Shiao , Jennifer M. McNiff , Jordan S. Pober
DOI: 10.4049/JIMMUNOL.175.8.4886
关键词: T cell 、 Inducible T-Cell Co-Stimulator Ligand 、 Priming (immunology) 、 Biology 、 Immunology 、 Adoptive cell transfer 、 ICOS LIGAND 、 Cancer research 、 CD8 、 4-1BB ligand 、 OX40 ligand
摘要: Both CD4 + and CD8 human memory but not naive T cells respond to allogeneic dermal microvascular endothelial (HDMEC) in vitro by secreting cytokines proliferating. Several recently identified costimulators, namely, 4-1BB ligand, ICOS OX40 are up-regulated on cultured HDMEC response TNF or coculture with cells. Blockade of these costimulators each partially reduces IFN-γ IL-2 secretion proliferation previously resting The effects overlapping identical. Memory the principal effectors injury skin allografts following adoptive transfer into immunodeficient mice. Furthermore, blocking ligand this model allograft cell effector molecule expression. These data demonstrate that can injure vivo without priming. several described contribute processes.
jimmunol.org参考文章(67)
W. W. Hancock, R. N. Salom, J. A. Maguire, D. Esmore, Analysis of proliferating cell nuclear antigen expression aids histological diagnosis and is predictive of progression of human cardiac allograft rejection. American Journal of Pathology. ,vol. 145, pp. 876- 882 ,(1994)
Bruce R. Blazar, Byoung S. Kwon, Angela Panoskaltsis-Mortari, Kyu B. Kwak, Jacques J. Peschon, Patricia A. Taylor, Ligation of 4-1BB (CDw137) Regulates Graft-Versus-Host Disease, Graft-Versus-Leukemia, and Graft Rejection in Allogeneic Bone Marrow Transplant Recipients Journal of Immunology. ,vol. 166, pp. 3174- 3183 ,(2001) , 10.4049/JIMMUNOL.166.5.3174
Tao Wen, Jacob Bukczynski, Tania H. Watts, 4-1BB ligand-mediated costimulation of human T cells induces CD4 and CD8 T cell expansion, cytokine production, and the development of cytolytic effector function. Journal of Immunology. ,vol. 168, pp. 4897- 4906 ,(2002) , 10.4049/JIMMUNOL.168.10.4897
Gülçin Demirci, Farhana Amanullah, Reshma Kewalaramani, Hideo Yagita, Terry B Strom, Mohamed H Sayegh, Xian Chang Li, None, Critical Role of OX40 in CD28 and CD154-Independent Rejection Journal of Immunology. ,vol. 172, pp. 1691- 1698 ,(2004) , 10.4049/JIMMUNOL.172.3.1691
Mark A DeBenedette, Tao Wen, Martin F Bachmann, Pamela S Ohashi, Brian H Barber, Kim L Stocking, Jacques J Peschon, Tania H Watts, None, Analysis of 4-1BB Ligand (4-1BBL)-Deficient Mice and of Mice Lacking Both 4-1BBL and CD28 Reveals a Role for 4-1BBL in Skin Allograft Rejection and in the Cytotoxic T Cell Response to Influenza Virus Journal of Immunology. ,vol. 163, pp. 4833- 4841 ,(1999)
Yifa Chen, Peter S. Heeger, Anna Valujskikh, In Vivo Helper Functions of Alloreactive Memory CD4+ T Cells Remain Intact Despite Donor-Specific Transfusion and Anti-CD40 Ligand Therapy Journal of Immunology. ,vol. 172, pp. 5456- 5466 ,(2004) , 10.4049/JIMMUNOL.172.9.5456
James A. Schulak, Neil S. Greenspan, Peter S. Heeger, Magdalena Tary-Lehmann, Donald E. Hricik, Cora Dejelo, Shannon Kuhlenschmidt, Pretransplant frequency of donor-specific, IFN-gamma-producing lymphocytes is a manifestation of immunologic memory and correlates with the risk of posttransplant rejection episodes. Journal of Immunology. ,vol. 163, pp. 2267- 2275 ,(1999)
Steven K. Yoshinaga, John S. Whoriskey, Sanjay D. Khare, Ulla Sarmiento, Jane Guo, Tom Horan, Grace Shih, Ming Zhang, Marco A. Coccia, Tadahiko Kohno, Anna Tafuri-Bladt, David Brankow, Pauline Campbell, David Chang, Laura Chiu, Tianang Dai, Gordon Duncan, Gary S. Elliott, Ariela Hui, Susan M. McCabe, Sheila Scully, Arda Shahinian, Christine L. Shaklee, Gwyneth Van, Tak W. Mak, Giorgio Senaldi, T-cell co-stimulation through B7RP-1 and ICOS Nature. ,vol. 402, pp. 827- 832 ,(1999) , 10.1038/45582
Engin Özkaynak, Wei Gao, Nida Shemmeri, Chichung Wang, Jose-Carlos Gutierrez-Ramos, Jillian Amaral, Shixin Qin, James B. Rottman, Anthony J. Coyle, Wayne W. Hancock, Importance of ICOS–B7RP-1 costimulation in acute and chronic allograft rejection Nature Immunology. ,vol. 2, pp. 591- 596 ,(2001) , 10.1038/89731
Jordan S. Pober, Weilie Ma, Human Endothelial Cells Effectively Costimulate Cytokine Production by, But Not Differentiation of, Naive CD4+ T Cells Journal of Immunology. ,vol. 161, pp. 2158- 2167 ,(1998)