The discovery of dopamine deficiency in the parkinsonian brain

作者: O. Hornykiewicz

DOI: 10.1007/978-3-211-45295-0_3

关键词: Basic scienceNeuroscienceMedicineDopamineParkinsonian brainDisease

摘要: This article gives a short historical account of the events and circumstances that led to discovery occurrence dopamine (DA) in brain its deficiency Parkinson’s disease (PD). Some important consequences, for both basic science patient, work on DA PD are also highlighted.

参考文章(38)
W. Raab, W. Gigee, Concentration and Distribution of “Encephalin” in the Brain of Humans, and Animals Experimental Biology and Medicine. ,vol. 76, pp. 97- 100 ,(1951) , 10.3181/00379727-76-18398
George C. Cotzias, Melvin H. Van Woert, Lewis M. Schiffer, Aromatic Amino Acids and Modification of Parkinsonism New England Journal of Medicine. ,vol. 276, pp. 374- 379 ,(1967) , 10.1056/NEJM196702162760703
Oleh Hornykiewicz, How L-DOPA was discovered as a drug for Parkinson's disease 40 years ago. Wiener Klinische Wochenschrift. ,vol. 113, pp. 855- 862 ,(2001)
Oleh Hornykiewicz, Dopamine and Parkinson's disease. A personal view of the past, the present, and the future. Advances in Neurology. ,vol. 86, pp. 1- 11 ,(2001)
Julián de Ajuriaguerra, Monoamines et système nerveux central Georg. ,(1962)
Dopamine in the CNS II Springer Berlin Heidelberg. ,(2002) , 10.1007/978-3-642-56051-4