CX3CL1 is up-regulated in the rat hippocampus during memory-associated synaptic plasticity.

摘要: Several cytokines and chemokines are now known to play normal physiological roles in the brain where they act as key regulators of communication between neurons, glia microglia. In particular, can affect cardinal cellular molecular processes hippocampal-dependent long-term memory consolidation including synaptic plasticity, scaling neurogenesis. The chemokine, CX3CL1 (fractalkine), has been shown modulate transmission potentiation (LTP) CA1 pyramidal cell layer hippocampus. Here, we confirm widespread expression on mature neurons adult rat We report an up-regulation protein CA1, CA3 dentate gyrus hippocampus 2 h after spatial learning water maze task. Moreover, same temporal increase was evident following potentiation-inducing theta-burst stimulation gyrus. At physiologically relevant concentrations, inhibited LTP maintenance This attenuation lost presence GABAA receptor/chloride channel antagonism. also had opposing actions glutamate-mediated rise intracellular calcium hippocampal organotypic slice cultures absence blockade. Using primary dissociated cultures, established that reduces rises both a dose dependent manner. conclusion, is up-regulated during brief window purpose which may be regulate neurotransmission tone. Our data supports possible role for this chemokine protective plasticity process scaling.