Diagnosis of urinary tract infection based on symptoms: how are likelihood ratios affected by age? a diagnostic accuracy study.

摘要: Objectives The aim of this study was to investigate the impact age on diagnostic properties typical symptoms urinary tract infection (UTI) in women presenting general practice with suggestive UTI significant bacteriuria as reference standard. Design Diagnostic accuracy study. Setting General practice, Copenhagen, Denmark. Participants Adult 15 years or older. Women where urine collected for investigation. Primary and secondary outcome measures Accuracy four (dysuria, frequency, urge abdominal pain) six different groups. Results 90 practices included 1178 adult women. prevalence varied between 30% aged 30–44 67% 75–89 years. likelihood ratios dysuria groups best performance 15–29 (positive ratio (pLR): 1.62 (1.30–1.94), negative (nLR): 0.36 (0.19–0.54)) (pLR: 1.74 (1.30–2.17), nLR: 0.48 (0.27–0.68)). CIs approximated one remaining most When were combined calculate post-test probabilities, effect varying values resulted a large variation probabilities Conclusions value well suspected vary considerable clinical implications. studies should take demographics such into consideration. Trial registration number ClinicalTrials.gov: NCT02698332.