Syntheses et activites biologiques de certains derives thyroxiniens et adrenergiques—IV.

摘要: Abstract -3:5 diiodinated derivatives of several 4 hydroxyphenylalcoylamines were synthetized so as to study some their adrenergic activities. The compounds tested on anesthetized and atropinized dogs. action the amines iododerivatives blood pressure cardiac rhythm was compared. data showed that diiodination had not same effect for each compound. presence secondary hydroxyl β- carbon atom critical. -4 hydroxyphenylethylamines (tyramine, N methyltyramine, hydroxyamphetamine, methyl hydroxyamphetamine) followed by a decrease hypertensive response both in intensity duration. opposite observed after iodination hydroxyphenylethanolamines (norsynephrine, synephrine, hydroxyephedrine). In this respect most active product diiodo hydroxyephedrine. On basis comparison between nuclear magnetic resonance spectra few phenolic hypothesis developed which explained part results.