Suppression of EIF4G2 by miR-379 potentiates the cisplatin chemosensitivity in nonsmall cell lung cancer cells.

摘要: Although microRNAs and EIF4G2 are both known to play pivotal roles in cancer progression, it remains unknown whether these pathways regulate chemosensitivity a coordinated manner. Here, we show that miR-379 expression is significantly downregulated chemoresistant non-small cell lung (NSCLC) tissues cells. Manipulation of levels could alter the vitro vivo cisplatin (CDDP) resistance (LCa) Mechanistically, potentiated LCa via modulation CDDP-induced apoptosis by directly targeting 3'UTR. Additionally, observed an inverse correlation between from patients with CDDP-based chemotherapy. Together, our findings shed new light on potential involvement miR-379/EIF4G2 cascade pathogenesis CDDP-resistance LCa. This article protected copyright. All rights reserved.