Scn4b regulates the hypnotic effects of ethanol and other sedative drugs

摘要: The voltage-gated sodium channel subunit β4 (SCN4B) regulates neuronal activity by modulating gating and has been implicated in ethanol consumption rodent models human alcoholics. However, the functional role for Scn4b ethanol-mediated behaviors is unknown. We determined if genetic global knockout (KO) or targeted knockdown of central nucleus amygdala (CeA) altered drinking related behaviors. used four different procedures (continuous intermittent two-bottle choice (2BC), drinking-in-the dark chronic vapor) found that male female KO mice did not differ from their wild-type (WT) littermates any tests. Knockdown mRNA CeA also alter 2BC drinking. showed longer duration loss righting reflex induced ethanol, gaboxadol, pentobarbital ketamine. slower recovery to basal levels handling-induced convulsions after injection, which consistent with increased sedative effects observed these mice. severity acute withdrawal. Acoustic startle responses, ethanol-induced hypothermia clearance blood between genotypes. There were no differences membrane properties excitability neurons WT Although we evidence mice, it was involved hypnotic other sedatives.