Parathyroid Hormone and Vitamin D Levels are Independently Associated With Calcific Aortic Stenosis

摘要: Background In calcific aortic valve disease, the early lesion is similar to atherosclerotic plaque, but later calcification prevails. Parathyroid hormone (PTH) and vitamin D are principal calcium pool regulators, so present study was designed assess their association with stenosis (AS) in patients significant coronary artery disease (CAD), preserved renal function. Methods Results The 122 consecutive AS (mean gradient ≥30 mmHg) plus CAD, 101 nonobstructive sclerosis ≤10 as controls, were prospectively enrolled. older (71±7 vs 66±7 years; p<0.001), had higher serum intact (i)PTH (51.4 [39-70] 37.4 [27-50] pg/ml; lower plasma (32.0 [25-40] 35.8 [27-55] nmol/L; p=0.003) levels than those sclerosis. groups did not differ significantly creatinine level (93 [82-105] 96 [85-107] μmol/L, p=0.19), - phosphate product, occurrence of hypertension, smoking, diabetes, dyslipidemia, or body mass index. iPTH (odds ratio (OR) 1.04, 95% confidence interval (CI) 1.02-1.05; p<0.001) (OR 0.97, CI 0.95-0.99; independently associated AS. Conclusion Higher CAD patients. (Circ J 2008; 72: 245 250)