Developing a new reference standard: is validation necessary?

摘要: Rationale and Objectives A gold standard is often an imperfect diagnostic test, falling short of achieving 100% accuracy in clinical practice. Using without fully comprehending its limitations biases can lead to erroneous classification patients with disease. This will ultimately affect treatment decisions patient outcomes. Therefore, validation essential before implementing a reference into Performing comprehensive process discussed, along advantages challenges. The different types methods are reviewed. An example from our work developing new for vasospasm diagnosis aneurysmal subarachnoid hemorrhage provided. Conclusion Employing may result definitional shift the disease scheme patients; therefore, it important also assess impact on outcomes effectiveness.