Recent animal models of alcoholism.

摘要: Animal models on alcohol preference have a long-standing tradition in biomedical research alcoholism. However, these allow only limited conclusions regarding addiction. Therefore, during the past 15 years, researchers developed new animal that mimic different aspects of human addiction, such as craving, relapse, and loss control over drinking. These include reinstatement model, deprivation point-of-no-return model. Some been pharmacologically validated with anti-craving compounds are used clinically for treating alcoholics. The detailed behavioral characterization their pharmacological validation also to study neurochemical molecular bases addictive behavior.