Mitomycin C: a clinical update.

摘要: Mitomycin C was reviewed in this journal 25 years ago and an update of its clinical usefulness is appropriate. The current review based on representative publications covering trials performed throughout the world. Single agent activity each major neoplastic diseases has been reassessed when possible most important combinations evaluated. It concluded that mitomycin a definite place treatment localized bladder cancer, active, but needs to be redefined, context newer regimens for breast, head neck, non-small cell lung cancers, active in, being displaced by, other drugs cervical, gastric pancreatic probably no longer therapeutic value colon cancer. also recognized as many treatments have success, role will require continuing re-investigation.