A facile access to 4-substituted-2-naphthols via a tandem Friedel-Crafts reaction: a β-chlorovinyl ketone pathway.
作者： Hun Young Kim , Kyungsoo Oh
DOI: 10.1021/OL502951V
关键词: Friedel–Crafts reaction 、 Chloride 、 Organic chemistry 、 Chemistry 、 Intramolecular force 、 Medicinal chemistry 、 Intermolecular force 、 Tandem 、 Acylation 、 Ketone 、 Alkylation
摘要: A one-pot synthesis of 2-naphthol derivatives is accomplished using a tandem Friedel–Crafts reaction sequence. The developed methodology allows for concomitant construction up to three C–C bonds between readily available alkynes and phenylacetyl chloride by an intermolecular acylation followed intramolecular alkylation β-chlorovinyl ketone intermediates.
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