Bromoethylsulfonium salt--a more effective annulation agent for the synthesis of 6- and 7-membered 1,4-heterocyclic compounds.

摘要: Reaction of bromoethylsulfonium salt with 1,2-/1,3-aminoalcohols gave six- and seven-membered rings in good-to-excellent yields. The reactions proceed through generation a vinyl sulfonium followed by annulation to give 1,4-heterocyclic compounds such as morpholines benzoxazepines simple procedure. method accommodates range nitrogen substituents the amino alcohol can be substituted thiols diamines thiomorpholines, piperazines benzodiazepines.