Hetero-annulation reaction between 2-acylnaphthoquinones and 2-aminobenzothiazoles. A new synthetic route to antiproliferative benzo[g]benzothiazolo[2,3-b]quinazoline-7,12-quinones
作者： Jaime A. Valderrama , David Ríos , Giulio G. Muccioli , Pedro Buc Calderon , Iván Brito
DOI: 10.1016/J.TETLET.2015.07.034
关键词: Annulation 、 Chemistry 、 Quinazoline 、 Stereochemistry 、 Combinatorial chemistry 、 Tumor cells
摘要: A convenient two-step method is developed for the preparation of benzo[g]benzothiazolo[2,3-b]quinazoline-7,12-quinones from 2-acylnaphthohydroquinones and 2-aminobenzothiazoles. The structure heterocyclic quinones supported by X-ray crystallography. This protocol provides an operationally simple strategy to prepare title compounds shows good functional flexibility easily available starting materials. Evidences are reported on significant in vitro antiproliferative activities some obtained prostate, bladder, breast human-derived tumor cell lines.
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