Active Site Binding Modes of HIV-1 Integrase Inhibitors

作者： Christoph A. Sotriffer , Ni , J. Andrew McCammon

关键词: Structure–activity relationship 、 Ligand 、 Integrase 、 Chemistry 、 Stereochemistry 、 Crystal structure 、 Docking (molecular) 、 Active site 、 Molecular model 、 Binding site

摘要: … active site conformations of a complexed state. Therefore the approximation of a rigid protein structure becomes less … 2 ) point toward the active site and are directly available for polar …