Prevalence and Risk of Potential Cytochrome P450–Mediated Drug-Drug Interactions in Older Hospitalized Patients with Polypharmacy
作者： Julie Doan , Hubert Zakrzewski-Jakubiak , Julie Roy , Jacques Turgeon , Cara Tannenbaum
DOI: 10.1345/APH.1R621
关键词: Internal medicine 、 Community hospital 、 Age and sex 、 Polypharmacy 、 Hospitalized patients 、 Cohort study 、 Intensive care medicine 、 Poisson regression 、 Prospective cohort study 、 Drug 、 Medicine
摘要: BACKGROUNDAs rates of polypharmacy rise and medication regimens become more complex, the risk potential cytochrome P450 (CYP)–mediated drug-drug interactions (DDIs) is a growing clinical concern for older adults.objective: To determine prevalence CYP-mediated DDIs in hospitalized adults with analyze relationship between number drugs dispensed probability these this high-risk population.METHODSA prospective 16-week cohort study was conducted among consecutive new patients aged 65 years (>5 drugs) admitted to community hospital. The profiles were analyzed multidrug cytochrome-specific software program. determined, calculated as function medications using multivariate Poisson regression adjusted age sex. Comparative performance program an...
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