Chronic Hepatitis E in Heart Transplant Recipients
作者： S. Pischke , P. Stiefel , B. Franz , B. Bremer , P. V. Suneetha
DOI: 10.1111/J.1600-6143.2012.04200.X
关键词: Hepatitis E 、 Hepatitis E virus 、 Internal medicine 、 Ribavirin 、 Survival rate 、 Cardiac surgery 、 Case-control study 、 Gastroenterology 、 Medicine 、 Immunology 、 Liver disease 、 Heart transplantation
摘要: Chronic courses of hepatitis E virus (HEV) infections have been described in immunosuppressed patients. We aimed to study the role HEV heart transplant recipients (HTR). 274 HTR were prospectively screened for infection using an anti-HEV-IgG ELISA and HEV-PCR. In addition, 137 patients undergoing cardiac surgery (non-HTR) 537 healthy subjects studied cross-sectionally. The seroprevalence was 11% HTR, 7% non-HTR 2% controls (HTR vs. p 200 IU/L histological or clinical evidence advanced liver disease. three ribavirin treatment successful with a sustained biochemical virological response while failed one cirrhotic patient after dose reduction. Heart increased risk infections. may explain elevated enzymes recipients. Treatment is effective but optimal duration therapy remains be determined.
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