Halogen interactions in biomolecular crystal structures

摘要: Electron-rich halogens are increasingly seen in biomolecular structures, particularly as they become incorporated into proteins and nucleic acids to facilitate phasing of X-ray diffraction data, ligands increase their efficacies inhibitors drugs. Recently, we have had reassess our basic understanding how contribute the structures stabilities biological macromolecules complexes, with recognition new classes non-covalent interactions that available Group IV atoms a rekindled interest halogen bonds. We review here current molecular properties these variety halogenated molecules important biology. Keywords: halogen interactions; aromatic bonds; halogen-bond acceptors; halogen-bond geometries