The Role of PI3K/Akt/mTOR Signaling in Gastric Carcinoma
作者： Tasuku Matsuoka , Masakazu Yashiro
关键词: Metastasis 、 Cell growth 、 Cancer research 、 Apoptosis 、 PI3K/AKT/mTOR pathway 、 Protein kinase B 、 RPTOR 、 Kinase 、 Signal transduction 、 Bioinformatics 、 Medicine
摘要: The phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) pathway is one the key signaling pathways induced by various receptor-tyrosine kinases. Accumulating evidence shows that this an important promoter cell growth, metabolism, survival, metastasis, and resistance to chemotherapy. Genetic alterations in PI3K/Akt/mTOR gastric carcinoma have often been demonstrated. Many kinds molecular targeting therapies are currently undergoing clinical testing patients with solid tumors. However, exception ErbB2-targeting antibody, agents, including inhibitors, not approved for treatment carcinoma. This review summarizes current knowledge on pathogenesis possible therapeutic targets Improved will be useful understanding mechanisms tumor development identifying ideal anticancer therapy
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Eiji Oki, Hideo Baba, Eriko Tokunaga, Toshihiko Nakamura, Naoyuki Ueda, Motonori Futatsugi, Kohjiro Mashino, Manabu Yamamoto, Masahiko Ikebe, Yoshihiro Kakeji, Yoshihiko Maehara, None, Akt phosphorylation associates with LOH of PTEN and leads to chemoresistance for gastric cancer International Journal of Cancer. ,vol. 117, pp. 376- 380 ,(2005) , 10.1002/IJC.21170
Brendan D. Manning, Lewis C. Cantley, AKT/PKB signaling: navigating downstream. Cell. ,vol. 129, pp. 1261- 1274 ,(2007) , 10.1016/J.CELL.2007.06.009
Yi-Chieh Lee, Tsan-Hwang Cheng, Jung-Shin Lee, Jiun-Hwan Chen, Yi-Chen Liao, Yao Fong, Cheng-Hsun Wu, Yuan-Wei Shih, Nobiletin, a citrus flavonoid, suppresses invasion and migration involving FAK/PI3K/Akt and small GTPase signals in human gastric adenocarcinoma AGS cells Molecular and Cellular Biochemistry. ,vol. 347, pp. 103- 115 ,(2011) , 10.1007/S11010-010-0618-Z
Huiqin Shen, Chunying Li, Shuang Han, Liu Hong, Yongquan Shi, Na Liu, Changcun Guo, Yan Xue, Taidong Qiao, Daiming Fan, Zheyi Han, Kaichun Wu, Akt1/protein Kinase Bα is Involved in Gastric Cancer Progression and Cell Proliferation Digestive Diseases and Sciences. ,vol. 53, pp. 1801- 1810 ,(2008) , 10.1007/S10620-007-9824-2
Valentina Fodale, Mariaelena Pierobon, Lance Liotta, Emanuel Petricoin, Mechanism of Cell Adaptation The Cancer Journal. ,vol. 17, pp. 89- 95 ,(2011) , 10.1097/PPO.0B013E318212DD3D
Zonglei Mao, Jin Zhou, Junwei Luan, Weihua Sheng, Xiaochun Shen, Xiaoqiang Dong, Tamoxifen reduces P-gp-mediated multidrug resistance via inhibiting the PI3K/Akt signaling pathway in ER-negative human gastric cancer cells. Biomedicine & Pharmacotherapy. ,vol. 68, pp. 179- 183 ,(2014) , 10.1016/J.BIOPHA.2013.10.003
Ana Ortega-Molina, Manuel Serrano, PTEN in cancer, metabolism, and aging Trends in Endocrinology & Metabolism. ,vol. 24, pp. 184- 189 ,(2013) , 10.1016/J.TEM.2012.11.002
Y Lu, M Muller, D Smith, B Dutta, K Komurov, S Iadevaia, D Ruths, J-T Tseng, S Yu, Q Yu, L Nakhleh, G Balazsi, J Donnelly, M Schurdak, S Morgan-Lappe, S Fesik, P T Ram, G B Mills, Kinome siRNA-phosphoproteomic screen identifies networks regulating AKT signaling. Oncogene. ,vol. 30, pp. 4567- 4577 ,(2011) , 10.1038/ONC.2011.164
Iwao Kobayashi, Shuho Semba, Yoshiko Matsuda, Yoshikazu Kuroda, Hiroshi Yokozaki, Significance of Akt Phosphorylation on Tumor Growth and Vascular Endothelial Growth Factor Expression in Human Gastric Carcinoma Pathobiology. ,vol. 73, pp. 8- 17 ,(2006) , 10.1159/000093087
Young-Hwa Kang, Hye Seung Lee, Woo Ho Kim, None, Promoter methylation and silencing of PTEN in gastric carcinoma. Laboratory Investigation. ,vol. 82, pp. 285- 291 ,(2002) , 10.1038/LABINVEST.3780422