Enantioselective transaminations by dendrimeric enzyme mimics
作者： Ronald Breslow , Sujun Wei , Craig Kenesky
DOI: 10.1016/J.TET.2007.02.052
关键词: Organic chemistry 、 Alanine 、 Dendrimer 、 Stereochemistry 、 Folding (chemistry) 、 Phenylalanine 、 Enantioselective synthesis 、 Chemistry 、 Pyridoxamine 、 Transamination 、 Enzyme
摘要: PAMAM dendrimers have been constructed with a pyridoxamine core and chiral capping amino groups. Transamination to form phenylalanine alanine from their related keto acids produced enantioselectivities induced by the formally remote caps, supporting computer models that indicate folding of dendrimer chains back into region.
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