Determining standardized causes of death of infants, children, and adolescents living with HIV in Asia.

摘要: Objective To implement a standardized cause of death reporting and review process to systematically disaggregate causes HIV-related deaths in cohort Asian children adolescents. Design Death-related data were retrospectively prospectively assessed longitudinal regional study. Methods Children under routine HIV care at sites Cambodia, India, Indonesia, Malaysia, Thailand, Vietnam between 2008 2017 followed. Causes reported then independently centrally reviewed. Predictors compared using competing risks survival regression analyses. Results Among 5918 children, 5523 (93%; 52% male) had ever been on combination antiretroviral therapy. Of 371 (6.3%) deaths, 312 (84%) occurred those with history therapy (crude all-cause mortality 9.6 per 1000 person-years; total follow-up time 32 361 person-years). In this group, median age was 7.0 (2.9-13) years; CD4 cell count 73 (16-325) cells/μl. The most common underlying pneumonia due unspecified pathogens (17%), tuberculosis (16%), sepsis (8.0%), AIDS (6.7%); 12% unknown. These clinical diagnoses further grouped into AIDS-related infections (22%) noninfections (5.8%), non-AIDS-related (47%) (11%); unknown, 2.2% not Higher better weight-for-age z-score protective against death. Conclusion Our assessment provides robust inform resource allocation for pediatric diagnostic evaluations prioritization interventions, highlight the continued importance opportunistic nonopportunistic as our cohort.