Effects of Application Site and Subject Demographics on the Pharmacokinetics of Fentanyl HCl Patient-Controlled Transdermal System (PCTS)
作者： Suneel K. Gupta , Stephen Hwang , Mary Southam , Gayatri Sathyan
DOI: 10.2165/00003088-200544001-00005
关键词: Demographics 、 Application site 、 Anesthesia 、 Transdermal 、 Route of administration 、 Fentanyl 、 Acute pain 、 Medicine 、 Pharmacokinetics 、 Patient demographics 、 Pharmacology (medical) 、 Pharmacology
摘要: Introduction: The fentanyl HCl patient-controlled transdermal system (PCTS) is a self-contained, preprogrammed, needle-free currently in development for acute pain management medically supervised setting. objectives of these studies were to evaluate skin application sites the PCTS and effect patient demographics on its pharmacokinetics.
springer.com
sci-hub.se 参考文章(4)
Richard B.R. Muijsers, Antona J. Wagstaff, Transdermal fentanyl: an updated review of its pharmacological properties and therapeutic efficacy in chronic cancer pain control. Drugs. ,vol. 61, pp. 2289- 2307 ,(2001) , 10.2165/00003495-200161150-00014
L.I. Harrison, D. Harari, An Evaluation of Bioequivalence of Two 7‐Day 17β‐Estradiol Transdermal Delivery Systems by Anatomical Site The Journal of Clinical Pharmacology. ,vol. 42, pp. 1134- 1141 ,(2002) , 10.1177/009127002401382740
Suneel K. Gupta, Keith J. Bernstein, Henk Noorduin, Achiel Van Peer, Gayatri Sathyan, Ron Haak, Fentanyl delivery from an electrotransport system : Delivery is a function of total current, not duration of current The Journal of Clinical Pharmacology. ,vol. 38, pp. 951- 958 ,(1998) , 10.1002/J.1552-4604.1998.TB04392.X
Jacques E. Chelly, Jeffrey Grass, Timothy W. Houseman, Harold Minkowitz, Alex Pue, The safety and efficacy of a fentanyl patient-controlled transdermal system for acute postoperative analgesia: a multicenter, placebo-controlled trial. Anesthesia & Analgesia. ,vol. 98, pp. 427- 433 ,(2004) , 10.1213/01.ANE.0000093314.13848.7E