The association between fracture and obesity is site-dependent: a population-based study in postmenopausal women.

摘要: The association between obesity and fracture is controversial. We investigated the relationship body mass index (BMI) at different skeletal sites in women aged ≥50 years using data from Sistema d' Informacio per al Desenvolupament de la Investigacio en Atencio Primaria (SIDIAP) database. SIDIAP contains computerized medical records of >3400 general practitioners Catalonia (northeastern Spain), with information on a representative 80% population (>5 million people). In 2009, 1,039,878 were eligible, whom 832,775 (80.1%) had BMI measurement. These categorized into underweight/normal (302,414 women), overweight (266,798), obese (263,563). Fractures ascertained International Classification Diseases, 10th revision (ICD-10) codes. Multivariate Poisson regression models fitted to adjust for age, smoking, high alcohol intake, type 2 diabetes, oral corticosteroid use. Hip fractures significantly less common than normal/underweight (rate ratio [RR] 0.77 [95% confidence interval (CI) 0.68 0.88], RR 0.63 CI 0.64 0.79], p < 0.001, respectively). Pelvis rates lower (RR 0.78 0.96], = 0.017) 0.58 0.47 0.73], 0.001) groups. Conversely, higher risk proximal humerus group 1.28 1.04 1.58], 0.018). Clinical spine, wrist, tibial, multiple rib not An age-related increase incidence was seen all groups sites; hip, clinical pelvis younger time women, whereas those wrist older. postmenopausal site-dependent, being protective against hip but associated an almost 30% when compared women. reasons these site-specific variations are unknown may be related patterns falls attenuation their impact by adipose tissue.