Exposure of normal and transformed cells to nevirapine, a reverse transcriptase inhibitor, reduces cell growth and promotes differentiation.

摘要: Endogenous, nontelomeric reverse transcriptase (RT) is encoded by two classes of repeated elements: retrotransposons and endogenous retroviruses. Expression RT-coding genes generally repressed in differentiated nonpathological tissues, yet active the mammalian germ line, embryonic tissues tumor cells. Nevirapine a non-nucleoside RT inhibitor with well-characterized inhibitory activity on enzymes retroviral origin. Here, we show that nevirapine also an effective murine human cell lines. In addition, progenitor transformed cells undergo significant reduction rate growth upon exposure to nevirapine. This accompanied onset differentiation, as depicted F9 C2C7 cultures which triggers expression differentiation-specific markers. Consistent this, extensive reprogramming cycle gene was nevirapine-treated cultures. Furthermore, rescued differentiation block present acute myeloid leukemia (AML) lines primary blasts from AML patients, indicated morphological, functional immunophenotypic assays. The finding can modulate proliferation suggests may represent novel target development therapeutical approaches neoplasia.