Application of fast atom bombardment with tandem mass spectrometry and liquid chromatography/ mass spectrometry to the analysis of acylcarnitines in human urine, blood, and tissue
作者： David S. Millington , Daniel L. Norwood , Naoki Kodo , Charles R. Roe , Fumio Inouet
DOI: 10.1016/0003-2697(89)90441-7
关键词: Isotope 、 Mass spectrometry 、 Fast atom bombardment 、 Tandem mass spectrometry 、 Deuterium 、 Liquid chromatography–mass spectrometry 、 Triple quadrupole mass spectrometer 、 Quantitative analysis (chemistry) 、 Chromatography 、 Chemistry
摘要: Using a precursor-ion scan function on triple quadrupole mass spectrometer, acylcarnitines were detected in the target matrices at or below concentrations of 1 nmol per gram by fast atom bombardment spectrometry. Acylcarnitine profiles from patients with known metabolic disorders consistent previously acquired data. Putative acylcarnitine signals confirmed one case administration stable isotope-labeled carnitine, which equilibrated rapidly endogenous pool. The addition continuous flow system enabled rapid sequential analysis without operator intervention, indicating potential for automation analytical procedure. Incorporation micro-LC column on-line liquid chromatographic/mass spectrometric selected patient samples. Large-scale screening and quantitative urine blood diagnostic are now practicable.
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sci-hub.se 参考文章(14)
C R Roe, D S Millington, D A Maltby, T P Bohan, C L Hoppel, L-carnitine enhances excretion of propionyl coenzyme A as propionylcarnitine in propionic acidemia. Journal of Clinical Investigation. ,vol. 73, pp. 1785- 1788 ,(1984) , 10.1172/JCI111387
C R Roe, D S Millington, D A Maltby, S G Kahler, T P Bohan, L-carnitine therapy in isovaleric acidemia. Journal of Clinical Investigation. ,vol. 74, pp. 2290- 2295 ,(1984) , 10.1172/JCI111657
David S. Millington, Charles R. Roe, David A. Maltby, Characterization of new diagnostic acylcarnitines in patients with β-ketothiolase deficiency and glutaric aciduria type I using mass spectrometry Journal of Mass Spectrometry. ,vol. 14, pp. 711- 716 ,(1987) , 10.1002/BMS.1200141204
Charles R. Roe, David S. Millington, David A. Maltby, P. Kinnebrew, Recognition of medium-chain acyl-CoA dehydrogenase deficiency in asymptomatic siblings of children dying of sudden infant death or Reye-like syndromes The Journal of Pediatrics. ,vol. 108, pp. 13- 18 ,(1986) , 10.1016/S0022-3476(86)80762-4
David S. Millington, Charles R. Roe, David A. Maltby, Application of high resolution fast atom bombardment and constant B/E ratio linked scanning to the identification and analysis of acylcarnitines in metabolic disease Biological Mass Spectrometry. ,vol. 11, pp. 236- 241 ,(1984) , 10.1002/BMS.1200110508
Kenneth B. Tomer, Nancy J. Jensen, Michael L. Gross, Joanne Whitney, Fast atom bombardment combined with tandem mass spectrometry for determination of bile salts and their conjugates. Journal of Mass Spectrometry. ,vol. 13, pp. 265- 272 ,(1986) , 10.1002/BMS.1200130602
Daniel L. Norwood, Naoki Kodo, David S. Millington, S. J. Gaskell, Application of continuous-flow liquid chromatography/fast-atom bombardment mass spectrometry to the analysis of diagnostic acylcarnitines in human urine. Rapid Communications in Mass Spectrometry. ,vol. 2, pp. 269- 272 ,(1988) , 10.1002/RCM.1290021205
C R Roe, D S Millington, D A Maltby, Identification of 3-methylglutarylcarnitine. A new diagnostic metabolite of 3-hydroxy-3-methylglutaryl-coenzyme A lyase deficiency. Journal of Clinical Investigation. ,vol. 77, pp. 1391- 1394 ,(1986) , 10.1172/JCI112446
J.A. Montgomery, O.A. Mamer, Measurement of urinary free and acylcarnitines: quantitative acylcarnitine profiling in normal humans and in several patients with metabolic errors. Analytical Biochemistry. ,vol. 176, pp. 85- 95 ,(1989) , 10.1016/0003-2697(89)90277-7
Yukio Ito, Toyohide Takeuchi, Daido Ishii, Masashi Goto, Direct coupling of micro high-performance liquid chromatography with fast atom bombardment mass spectrometry Journal of Chromatography A. ,vol. 346, pp. 161- 166 ,(1985) , 10.1016/S0021-9673(00)90502-8