LEUKAEMIC SUBCLONES IN CHRONIC MYELOGENOUS LEUKAEMIA

摘要: . Serial karyotype studies have been done during cytostatic treatment in a patient with CML blastic crisis. A course of cytosine arabinoside and thioguanine resulted dramatic decrease the frequency 54-chromosome clone simultaneous increases 46, XY 50-chromosome clone. At same time cytological composition bone marrow changed towards normal some temporary clinical improvement took place. Comparison data on karyotypes cytology suggest that highly abnormal represented myeloblasts promyelocytes, whereas early red cell precursors were cells. In discussion following suggestions are made: (A) Heterogeneity leukaemic population, as evidenced by differences karyotypes, may be associated drug sensitivity. This represents rationale for multiple therapy. (B) Differentiation cells not compatible karyotypes; turn, lack differentiation result growth advantage severe abnormalities, which would explain typical evolution from condition characterized single abnormality (the Ph1-chromosome) successful to state abnormalities differentiation, ending (C) It might possible postpone development crisis if was directed against developing clones chronic phase CML. is proposed study use intermittent intensive chemotherapy preliminary observation incipient malignant CML, secondary almost disappeared after thioguanine.