Brain infarction in sickle cell anemia: Magnetic resonance imaging correlates

摘要: Brain infarction is a well-known but poorly understood complication of sickle cell disease. Seventy-three disease patients underwent neurological examinations and high-field, heavily T2-weighted axial cranial magnetic resonance image (MRI) scanning. Eighteen the 73 had history stroke, defined as an acute, focal sign lasting longer than 1 hour; in event convulsive onset, MRI abnormality correlate was necessary. Sixteen 18 stroke demonstrated abnormalities consistent with arterial borderzone infarctions. Fifty-five no stroke. Six 55 (11%) suggesting previous subclinical Five these lesions were regions. The distinguishing feature 21 22 predilection for high cortical convexity, general regions borderzones between major cerebral arteries adjacent deep white matter. pattern suggests two pathogenetic mechanisms: (1) proximal large-vessel inadequate perfusion (distal field insufficiency syndrome) (2) distal small-vessel (sludging syndrome).