Exogenous interleukin‐10 attenuates hyperoxia‐induced acute lung injury in mice

摘要: New Findings What is the central question of this study? It not known whether treatment with interleukin-10 (IL-10) attenuates hyperoxia-induced acute lung injury in mice. What main finding and its importance? Our results showed that exogenous IL-10 alleviated mice, possibly by regulating neutrophil recruitment subsequent generation cytokines, nitric oxide matrix metalloproteinases. Lung caused breathing air enriched oxygen continues to be a major problem clinical medicine. Here, we investigated therapeutic role mice. In first experiment, mice were exposed room or 95% O2 treated simultaneously. second wild-type IL-10−/− O2. Exogenous attenuated injury, evidenced reduced ratio weight body weight, wet dry cell numbers protein content bronchoalveolar lavage fluid death. Interleukin-10 markedly prolonged survival during exposure. activity myeloperoxidase mRNA levels interleukin-6, tumour necrosis factor-α macrophage inflammatory protein 2, suppressed nuclear factor-κB activation decreased inducible synthnase expression formation lungs hyperoxia. activities metalloproteinase 2 metalloproteinase 9 permeability Furthermore, absence aggravated duration exposure, which was IL-10. conclusion, our show alleviates metalloproteinases. This suggests may promising strategy reduce patients