Bioactive Metabolites from Mangrove Endophytic Fungus Aspergillus sp. 16-5B.
作者： Yayue Liu , Senhua Chen , Zhaoming Liu , Yongjun Lu , Guoping Xia
DOI: 10.3390/MD13053091
关键词: Isocoumarin 、 IC50 、 Stereochemistry 、 Aspergillus 、 Alpha-glucosidase 、 Circular dichroism 、 Non-competitive inhibition 、 Biology 、 Absolute configuration 、 Two-dimensional nuclear magnetic resonance spectroscopy
摘要: Chemical investigation of the endophytic fungus Aspergillus sp. 16-5B cultured on Czapek’s medium led to isolation four new metabolites, aspergifuranone (1), isocoumarin derivatives (±) 2 and 3, (R)-3-demethylpurpurester A (4), together with known purpurester B (5) pestaphthalides (6). Their structures were determined by analysis 1D 2D NMR spectroscopic data. The absolute configuration Compound 1 was comparison experimental calculated electronic circular dichroism (ECD) spectra, that 4 revealed comparing its optical rotation data CD those literature. structure 6 further confirmed single-crystal X-ray diffraction experiment using CuKα radiation. All isolated compounds evaluated for their α-glucosidase inhibitory activities, showed significant activity IC50 value 9.05 ± 0.60 μM. Kinetic a noncompetitive inhibitor α-glucosidase. Compounds exhibited moderate activities.
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