Androgen receptor CAG repeat length as a moderator of the relationship between free testosterone levels and cognition

摘要: Age-related decrease in testosterone levels is a potential risk factor for cognitive decline older men. However, observational studies and clinical trials have reported inconsistent results on the effects of individual domains. Null findings may be attributed to factors that yet consider. In particular, variations polyglutamine (CAG) length androgen receptor (AR) gene could alter androgenic activity brain regions associated with processes including memory executive functions. role AR CAG repeat as moderator relationship between cognition has not been investigated. Therefore, we aimed examine baseline calculated free (cFT) levels, change cFT over 18 months performance memory, function, language, attention processing speed These relationships were examined 304 cognitively normal male participants Australian Imaging, Biomarkers Lifestyle (AIBL) Study Ageing. domain, short appears exacerbate low are also lower than expected at follow-up. highlight should considered future complex cognition.