Reduction of AEDs in Postsurgical Patients Who Attain Remission

摘要: Summary: Purpose: Little evidence guides practice regarding the reduction of antiepileptic drugs (AEDs) in individuals who achieve significant periods remission after resective surgery. Methods: In a prospective study 396 underwent surgery for intractable seizures, impact reducing AEDs on relapse and predictors were examined. Results: Of 301 subjects attained 1-year seizure surgery, 129 reduced from two to one or no achieving remission, 162 did not reduce drugs. Ten patients stopped all before attaining excluded analysis. all, 114 (39%) relapsed: 73 (45%) nonreduction group 41 (32%) (p = 0.02). Patients more likely have remitted immediately hospital discharge (p<0.0001). After adjustment this factor, little apparent drug rate was noted [rate ratio (RR), 1.1; 95% CI, 0.72–1.71; p=0.64 AED, RR, 0.85; 0.50–1.45; p=0.56 AEDs]. Within AEDs, only delayed significantly associated with an increased (RR, 2.26; 1.15– 4.48; p=0.02). Continued auras had marginally association 2.06; p=0.07) Conclusions: Although many relapses cohort postsurgical achieved occurred context completely eliminating risk higher than those continued AEDs. Randomized studies are needed test seizure-free patients.