38 Sphingoid long chain bases prevent lung infection by Pseudomonas aeruginosa
作者： Y. Pewzner-Jung , S.T. Tabazavareh , H. Grassmé , K.A. Becker , L. Japtok
DOI: 10.1016/S1569-1993(15)30215-0
关键词: Acid Ceramidase 、 Cystic fibrosis 、 Inhalation 、 Lung 、 Ceramide 、 Pseudomonas aeruginosa 、 Pathogen 、 Medicine 、 Immunology 、 Sphingosine
摘要: Physiological innate defense mechanisms against lung pathogens, and their alterations in lung diseases, are mostly unknown. Tracheal and bronchial sphingosine levels were significantly reduced in tissues from cystic fibrosis patients and mouse models due to reduced activity of acid ceramidase, which generates sphingosine from ceramide. This was shown by various methods including enzymatic assays, immunohistochemistry and mass spectrometry. Inhalation of mice with sphingosine, and its analog FTY720, or with acid …
cysticfibrosisjournal.com
elsevier.com参考文章(23)
Nikoletta Charizopoulou, Martina Wilke, Martina Dorsch, Alice Bot, Huub Jorna, Silke Jansen, Frauke Stanke, Hans J Hedrich, Hugo R de Jonge, Burkhard Tümmler, Spontaneous rescue from cystic fibrosis in a mouse model. BMC Genetics. ,vol. 7, pp. 18- 18 ,(2006) , 10.1186/1471-2156-7-18
Debra Jan Bibel, Raza Aly, Henry R Shinefield, Antimicrobial activity of sphingosines. Journal of Investigative Dermatology. ,vol. 98, pp. 269- 273 ,(1992) , 10.1111/1523-1747.EP12497842
Elza Rakhimova, Lutz Wiehlmann, Aimee L. Brauer, Sanjay Sethi, Timothy F. Murphy, Burkhard Tümmler, Pseudomonas aeruginosa Population Biology in Chronic Obstructive Pulmonary Disease The Journal of Infectious Diseases. ,vol. 200, pp. 1928- 1935 ,(2009) , 10.1086/648404
Annette E. LaBauve, Matthew J. Wargo, Detection of Host-Derived Sphingosine by Pseudomonas aeruginosa Is Important for Survival in the Murine Lung PLoS Pathogens. ,vol. 10, pp. e1003889- ,(2014) , 10.1371/JOURNAL.PPAT.1003889
A. D. Cox, S. G. Wilkinson, Ionizing groups in lipopolysaccharides of Pseudomonas cepacia in relation to antibiotic resistance Molecular Microbiology. ,vol. 5, pp. 641- 646 ,(1991) , 10.1111/J.1365-2958.1991.TB00735.X
Carol L. Fischer, David R. Drake, Deborah V. Dawson, Derek R. Blanchette, Kim A. Brogden, Philip W. Wertz, Antibacterial Activity of Sphingoid Bases and Fatty Acids against Gram-Positive and Gram-Negative Bacteria Antimicrobial Agents and Chemotherapy. ,vol. 56, pp. 1157- 1161 ,(2012) , 10.1128/AAC.05151-11
Yael Pewzner-Jung, Hyejung Park, Elad L. Laviad, Liana C. Silva, Sujoy Lahiri, Johnny Stiban, Racheli Erez-Roman, Britta Brügger, Timo Sachsenheimer, Felix Wieland, Manuel Prieto, Alfred H. Merrill, Anthony H. Futerman, A Critical Role for Ceramide Synthase 2 in Liver Homeostasis: I. ALTERATIONS IN LIPID METABOLIC PATHWAYS* Journal of Biological Chemistry. ,vol. 285, pp. 10902- 10910 ,(2010) , 10.1074/JBC.M109.077594
Chi-Ming Li, Seung-Beom Hong, Guido Kopal, Xingxuan He, Thomas Linke, Wu-Shiun Hou, Jürgen Koch, Shimon Gatt, Konrad Sandhoff, Edward H. Schuchman, Cloning and Characterization of the Full-Length cDNA and Genomic Sequences Encoding Murine Acid Ceramidase Genomics. ,vol. 50, pp. 267- 274 ,(1998) , 10.1006/GENO.1998.5334
Junko Arikawa, Mutsumi Ishibashi, Makoto Kawashima, Yutaka Takagi, Yoshiaki Ichikawa, Genji Imokawa, Decreased Levels of Sphingosine, a Natural Antimicrobial Agent, may be Associated with Vulnerability of the Stratum Corneum from Patients with Atopic Dermatitis to Colonization by Staphylococcus aureus Journal of Investigative Dermatology. ,vol. 119, pp. 433- 439 ,(2002) , 10.1046/J.1523-1747.2002.01846.X
A. T. McManus, A. D. Mason, W. F. McManus, B. A. Pruitt, Twenty-five year review of Pseudomonas aeruginosa bacteremia in a burn center European Journal of Clinical Microbiology & Infectious Diseases. ,vol. 4, pp. 219- 223 ,(1985) , 10.1007/BF02013601