Presynaptic cross-talk of β-adrenoreceptor and 5-hydroxytryptamine receptor signalling in the modulation of glutamate release from cerebrocortical nerve terminals
作者： Su-Jane Wang , Victoria Coutinho , Talvinder S Sihra
关键词: Metabotropic glutamate receptor 、 Long-term potentiation 、 Receptor 、 Inhibitory postsynaptic potential 、 Biology 、 Isoprenaline 、 Glutamate receptor 、 Glutamic acid 、 Internal medicine 、 Endocrinology 、 Agonist
摘要: The presynaptic interactions between facilitatory β-adrenoreceptors and inhibitory 5-hydroxytryptamine (5-HT) receptors modulating glutamate release from cerebrocortical nerve terminals were examined. 4-Aminopyridine (4-AP, 1 mM)-evoked was facilitated by the membrane permeant cyclic-3′,5′-adenosine monophosphate (cAMP) analogue, 8-bromo-cAMP (8-Br-cAMP), used to directly activate cAMP-dependent protein kinase (PKA). The β-adrenoreceptor agonist, isoprenaline (ISO), effected a concentration-dependent potentiation of 4-AP-evoked which abolished antagonist, propranolol, PKA inhibitor, Rp-cyclic-3′,5′-adenosine-monophosphothioate (Rp-cAMPS). 5-HT receptor activation 100 μM 5-HT produced an inhibition in terminals. effect could be mimicked selective 5-HT1A 8-hydroxy-dipropylaminotetralin (8-OH-DPAT) antagonized 1-(2-methoxyphenyl)-4-(4-phthalimidobutyl)piperazine (NAN-190). When (or 8-OH-DPAT) conjunction with ISO or 8-Br-cAMP, β-adrenoreceptor- PKA-mediated abrogated. The crosstalk β-adrenoceptor-mediated facilitation presence NAN-190. Examination voltage-dependent Ca2+ influx revealed that, while alone caused respective diminution increase [Ca2+]c, co-presence mediated influx. Together, these results suggest that coexist on cross-talk two signalling pathways occurs at locus downstream cAMP production, possibly level influx. British Journal Pharmacology (2002) 137, 1371–1379. doi:10.1038/sj.bjp.0705045
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