Action of angiotensin II on the isolated intact heart

摘要: Current data support an angiotensin (Ang) II-forming pathway in the heart. The expression of angiotensinogen, angiotensin-converting enzyme (ACE), receptors (AT1 and AT2), renin has been demonstrated on both mRNA protein levels, a number actions have related to activation this local renin–angiotensin system Although final physiological pathophysiological role cardiac remains be determined, there is growing evidence that production Ang II functional importance. Specifically, studies isolated working hearts helped separate effects systemic systems. For example, some pharmacological ACE inhibitors are sustained even absence any circulating component system. Thus, from suggest significant contribution tissue or, vice versa action its inhibitors. These may include induction myocyte growth, coronary vasoconstriction, positive inotropy, negative lusitropy, as well postischemic reperfusion arrhythmias injuries. heart investigated extensively. This article will focus system, which performed beating hearts.