Critical Scales Govern the Mechanical Fragmentation Mechanisms of Biomolecular Assemblies
作者： Matthew Sullivan , Sinan Keten
DOI: 10.1115/1.4023681
关键词: Scaling 、 Curvature 、 Classical mechanics 、 Materials science 、 Shock (mechanics) 、 Relaxation (physics) 、 Binding energy 、 Chemical physics 、 Fragmentation (mass spectrometry) 、 Shock wave 、 Molecular dynamics
摘要: Fragmentation mechanisms of peptide assemblies under shock deformation are studied using molecular dynamics simulations and found to depend strongly on the relative magnitude front radius fibril length ratio impact energy cohesive energy. The competition between size scaling curvature leads a mechanism change at critical velocity, developing stark contrast in fragmentation low high strain rates. We show that can be classified basis time scales relaxation provide new insight into experimental observations.
asme.org
harvard.edu
sci-hub.se 参考文章(47)
Gregory A Voth, None, Coarse-Graining of Condensed Phase and Biomolecular Systems CRC Press. ,(2008) , 10.1201/9781420059564
Philip LeDuc, Charbel Haber, Gang Bao, Denis Wirtz, Dynamics of individual flexible polymers in a shear flow Nature. ,vol. 399, pp. 564- 566 ,(1999) , 10.1038/21148
Rami Hourani, Chen Zhang, Rob van der Weegen, Luis Ruiz, Changyi Li, Sinan Keten, Brett A. Helms, Ting Xu, Processable Cyclic Peptide Nanotubes with Tunable Interiors Journal of the American Chemical Society. ,vol. 133, pp. 15296- 15299 ,(2011) , 10.1021/JA2063082
N. S. Yang, J. Burkholder, B. Roberts, B. Martinell, D. McCabe, In vivo and in vitro gene transfer to mammalian somatic cells by particle bombardment. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 87, pp. 9568- 9572 ,(1990) , 10.1073/PNAS.87.24.9568
Anton Arkhipov, Peter L. Freddolino, Katsumi Imada, Keiichi Namba, Klaus Schulten, Coarse-grained molecular dynamics simulations of a rotating bacterial flagellum. Biophysical Journal. ,vol. 91, pp. 4589- 4597 ,(2006) , 10.1529/BIOPHYSJ.106.093443
H Zhang, K Ravi-Chandar, Dynamic fragmentation of ductile materials Journal of Physics D. ,vol. 42, pp. 214010- ,(2009) , 10.1088/0022-3727/42/21/214010
Gérald Guérin, Hai Wang, Ian Manners, Mitchell A. Winnik, Fragmentation of fiberlike structures: sonication studies of cylindrical block copolymer micelles and behavioral comparisons to biological fibrils. Journal of the American Chemical Society. ,vol. 130, pp. 14763- 14771 ,(2008) , 10.1021/JA805262V
Yumiko Ohhashi, Miho Kihara, Hironobu Naiki, Yuji Goto, Ultrasonication-induced Amyloid Fibril Formation of β2-Microglobulin Journal of Biological Chemistry. ,vol. 280, pp. 32843- 32848 ,(2005) , 10.1074/JBC.M506501200
Markus A. Hartmann, Peter Fratzl, Sacrificial Ionic Bonds Need To Be Randomly Distributed To Provide Shear Deformability Nano Letters. ,vol. 9, pp. 3603- 3607 ,(2009) , 10.1021/NL901816S