How to train glioma cells to die: molecular challenges in cell death

摘要: The five-year survival rate for patients with malignant glioma is less than 10 %. Despite aggressive chemo/radiotherapy these tumors have remained resistant to almost every interventional strategy evaluated in patients. Resistance agents attributed extrinsic mechanisms such as the tumor microenvironment, poor drug penetration, and tumoral heterogeneity. In addition, genetic molecular examination of has revealed defective apoptotic regulation, enhanced pro-survival autophagy signaling, a propensity necrosis that aids adaptation environmental stress resistance treatment. combination intrinsic hallmarks contributes multifaceted traditional anti-tumor agents. Here we describe biology disease relevant therapeutic resistance, specific focus on deregulation cell death pathways. Emerging studies investigating targeting pathways including BH3 mimetics inhibitors are being both preclinical clinical settings discussed. This review highlights exploited by glioblastoma cells drive their hallmark predisposition makes therapy development challenge.