New stable synthetic bacteriochlorins for photodynamic therapy of melanoma

摘要: Photodynamic therapy (PDT) has been successfully used to treat many malignancies, and afforded highly encouraging results in skin cancers such as basal cell carcinoma. However, pigmented melanoma remains a notable exception from the range of tumors treated by PDT largely due fact that melanin high absorption light wavelength regions where most clinically approved photosensitizers (PS) absorb (600-690 nm). Moreover, cells sequester exogenous molecules including inside melanosomes. The aforementioned drawbacks PS have motivated us search for new classes with improved spectral properties, bacteriochlorins (BC) be melanoma. To overcome PDT-resistance mechanisms melanoma, particularly optical melanin, three near-infrared (NIR) absorbing synthetic stable BC were treatment Dose fluence dependent killing, intracellular localization (particularly melanosomes), correlation between level death examined. Intracellular melanosomes are ruptured after illumination shown electron microscopy. best vitro performing tested upon delivery micellar nanoparticles against mouse Two effective at significantly lower concentrations (<0.5 μM) than common present use.