Metabolic Actions of Growth Hormone

摘要: Growth hormone (GH) and insulin-like growth factor-1 (IGF-1) exert profound effects on energy, lipid, protein, carbohydrate metabolism. GH increases energy expenditure, lipolysis, lipid oxidation, actions that account for the reduction in fat mass during replacement. The increase lean body skeletal muscle induced by is mediated an protein synthesis a irreversible oxidative loss of amino acids. While excess causes insulin resistance, effect lower doses metabolism variable dependent changes abdominal adiposity, IGF-1. IGF-1 augments some metabolic GH, but counteracts others. Like reducing oxidation increasing synthesis. However, has partially offsets excess. likely to be indirectly secretion. Finally, there not single Rather, spectrum determined dose, duration use, underlying disease state. Integration many variables needed explain acromegaly deficiency replacement latter.