Impact of Socioeconomic Status, Race, and Ethnicity on Quality of Life in Patients With Cystic Fibrosis in the United States

摘要: Background Patient-reported outcomes are increasingly used in clinical trials to assess the natural history of chronic diseases and efficacy new treatments. Understanding effects socioeconomic minority status on health-related quality life (HRQOL) will facilitate interpretation results suggest targets for interventions improve patient care outcomes. The objective this study was examine HRQOL patients with cystic fibrosis (CF) from childhood through adulthood a large, comprehensive database containing medical data CF. Methods A cross-sectional performed using obtained Epidemiologic Study Cystic Fibrosis 4,751 1,826 parents who were non-Hispanic white, African-American, or Hispanic completed Questionnaire-Revised (CFQ-R), disease-specific measure, during stable clinic visit. Results Multivariate models assessed main Regression that controlled disease severity identified contributions these two variables HRQOL. Low associated significantly lower CFQ-R scores children, parents, adults majority domains. After controlling status, African-American reported worse emotional social functioning. Conclusions may affect important patient-reported CF across their span.