Epidemiological, clinical and virological characteristics of 74 cases of coronavirus-infected disease 2019 (COVID-19) with gastrointestinal symptoms.

摘要: Objective The SARS-CoV-2-infected disease (COVID-19) outbreak is a major threat to human beings. Previous studies mainly focused on Wuhan and typical symptoms. We analysed 74 confirmed COVID-19 cases with GI symptoms in the Zhejiang province determine epidemiological, clinical virological characteristics. Design hospital patients were admitted from 17 January 2020 8 February 2020. Epidemiological, demographic, clinical, laboratory, management outcome data of using multivariate analysis for risk severe/critical type. Bioinformatics used analyse features SARS-CoV-2 province. Results Among enrolled 651 patients, (11.4%) presented at least one symptom (nausea, vomiting or diarrhoea), average age 46.14 years, 4-day incubation period 10.8% had pre-existing liver disease. Of symptoms, (22.97%) 23 (31.08%) types family clustering, respectively, significantly higher than those without 47 (8.14%) 118 (20.45%). 29 (39.19%), (31.08%), (10.81%) 16 (21.62%) rates fever >38.5°C, fatigue, shortness breath headache, respectively. Low-dose glucocorticoids antibiotics administered 14.86% 41.89% Sputum production increased lactate dehydrogenase/glucose levels factors showed sequence mutation m6A methylation changed binding capacity ACE2. Conclusion report novel outside Wuhan. Attention non-classic should increase protect health providers.