NAD (P) H Quinine Oxidoreductase (NQO1) as a Risk Modifier of Susceptibility to Chronic Myeloid Leukaemia in Sudan

摘要: CML is the most prevalent haematological cancer among Sudanese population. Previous studies reported an association between NQO1 polymorphism and leukaemia, however these showed differences in occurrence frequency of this relationship. This study aimed to examine C609T with risk clinical outcome Philadelphia positive patients Sudan. The included 73 newly diagnosed patients, their genotypes (detected by PCR/RFLP) characteristics (determined Sysmex KX-21N) were determined compared 60 age sex matched normal subjects as control. When 609CC genotype was defined reference, a 3.5-fold increased for those carrying 609CT (heterozygous) observed (OR 3.461, P value 0.016). 609 TT (homozygous) higher 1.7 folds than control group, but no statistical significance 1.718, 0.305). combined together (mutant types) significantly 2.5- fold when controls 2.522, 0.019). We statistically significant reduction mean Hb level mutant wild type (p 0.037), WBCs count, platelet basophiles count blasts 0.024, 0.020, 0.024 0.000) respectively. In conclusion, our results indicate that genotypes, low enzymatic activity, are associated worse outcome.