RARs and MicroRNAs

摘要: MicroRNAs (miRNAs) are small noncoding RNAs acting as endogenous regulators of gene expression. Their discovery is one the major recent breakthroughs in molecular biology. miRNAs establish a multiplicity relationships with target mRNAs and exert pleiotropic biological effects many cell physiological pathways during development adult life. The dynamic nature expression regulation by Retinoic Acid (RA) consistent an extensive functional interplay miRNA activities. In fact, RA regulates different miRNAs, thus suggesting relevant function RA-controlled programmes. have been extensively studied targets mediators activity embryonic well normal neoplastic cells. However, relatively few studies experimentally explored direct contribution to signalling pathway. Here, we provide overview mechanistic aspects that allow biogenesis, activation regulation, focusing on evidence highlights between RA-regulated networks. We report examples tissue-specific roles modulated stem pluripotency maintenance regeneration, development, hematopoietic neural differentiation, other model systems, underlining their role disease pathogenesis. also address novel areas research linking pathway nuclear miRNAs.