Overview of Nrf2 as Therapeutic Target in Epilepsy
作者： Liliana Carmona-Aparicio , Claudia Pérez-Cruz , Cecilia Zavala-Tecuapetla , Leticia Granados-Rojas , Liliana Rivera-Espinosa
关键词: Pharmacology 、 Antioxidant 、 Cellular redox 、 Epilepsy 、 Transcription factor 、 Bioinformatics 、 Signal transduction 、 Oxidative stress 、 Neurological disorder 、 Biology 、 Antioxidant Response Elements
摘要: Oxidative stress is a biochemical state of imbalance in the production reactive oxygen and nitrogen species antioxidant defenses. It involved physiopathology degenerative chronic neuronal disorders, such as epilepsy. Experimental evidence humans animals support involvement oxidative before after seizures. In past few years, research has increasingly focused on molecular pathways this process, that involving transcription factor nuclear E2-related 2 (Nrf2), which plays central role regulation response elements (ARE) modulates cellular redox status. The aim review to present experimental Nrf2 neurological disorder further determine therapeutic impact
mdpi.com
doaj.org
core.ac.uk 参考文章(112)
Sidney Starkman, Jerome Engel, Overview of Seizures Emergency Medicine Clinics of North America. ,vol. 12, pp. 895- 923 ,(1994) , 10.1016/S0733-8627(20)30386-2
L Forsgren, A Carpio, NE Bharucha, M Sillanpaa, J Engel, J Cereghino, AW Hauser, J Fernandes, H Rwiza, P Jallon, S AlDeeb, EH Reynolds, R Elwes, P Wolf, Jwas Sander, The Epidemiology of the Epilepsies: Future Directions Epilepsia. ,vol. 38, pp. 614- 618 ,(1997)
Albrecht Wendel, [44] Glutathione peroxidase Methods in Enzymology. ,vol. 77, pp. 325- 333 ,(1981) , 10.1016/S0076-6879(81)77046-0
Lauren E. Tebay, Holly Robertson, Stephen T. Durant, Steven R. Vitale, Trevor M. Penning, Albena T. Dinkova-Kostova, John D. Hayes, Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease Free Radical Biology and Medicine. ,vol. 88, pp. 108- 146 ,(2015) , 10.1016/J.FREERADBIOMED.2015.06.021
Manuela Mazzuferi, Gaurav Kumar, Jonathan van Eyll, Benedicte Danis, Patrik Foerch, Rafal M. Kaminski, Nrf2 defense pathway: Experimental evidence for its protective role in epilepsy Annals of Neurology. ,vol. 74, pp. 560- 568 ,(2013) , 10.1002/ANA.23940
Mohammad Ghofrani, Childhood Headache Syndromes (Part II) Iranian journal of child neurology. ,vol. 4, pp. 7- 14 ,(2010) , 10.22037/IJCN.V4I2.1864
Javad Akhondian, Mohammad Ghofrani, INTRACTABLE EPILEPSY IN CHILDREN Iranian journal of child neurology. ,vol. 4, pp. 7- 14 ,(2010) , 10.22037/IJCN.V4I3.1999
Andrew D. Kraft, Jong-Min Lee, Delinda A. Johnson, Yuet Wai Kan, Jeffrey A. Johnson, Neuronal sensitivity to kainic acid is dependent on the Nrf2-mediated actions of the antioxidant response element. Journal of Neurochemistry. ,vol. 98, pp. 1852- 1865 ,(2006) , 10.1111/J.1471-4159.2006.04019.X
Marcelo G Bonini, Marcia EL Consolaro, Peter C Hart, Mao Mao, Andre Luelsdorf Pimenta De Abreu, Alyssa M Master, None, Redox control of enzymatic functions: The electronics of life's circuitry. Iubmb Life. ,vol. 66, pp. 167- 181 ,(2014) , 10.1002/IUB.1258
Y Li, A.K. Jaiswal, Regulation of human NAD(P)H:quinone oxidoreductase gene. Role of AP1 binding site contained within human antioxidant response element. Journal of Biological Chemistry. ,vol. 267, pp. 15097- 15104 ,(1992) , 10.1016/S0021-9258(18)42151-5