Activated protein C therapy in a rat heat stroke model.
作者： Chin-Ming Chen , Ching-Cheng Hou , Kuo-Chen Cheng , Ru-Ling Tian , Ching-Ping Chang
DOI: 10.1097/01.CCM.0000224231.01533.B1
关键词: Stroke 、 Tumor necrosis factor alpha 、 Dose–response relationship 、 Hyperthermia 、 Surgery 、 Pharmacology 、 Blood urea nitrogen 、 Medicine 、 Therapeutic effect 、 Protein C 、 Intensive care
摘要: Objective:To evaluate the therapeutic effects of activated protein C in an animal model heat stroke.Design:Laboratory investigation.Setting:Chi-Mei Medical Center research laboratory.Subjects:Male Sprague-Dawley rats weighing 252–304 g.Interventions:Anesthetized animals were subjected to str
sci-hub.se 参考文章(47)
Y Sakata, DJ Loskutoff, CL Gladson, CM Hekman, JH Griffin, Mechanism of protein C-dependent clot lysis: role of plasminogen activator inhibitor Blood. ,vol. 68, pp. 1218- 1223 ,(1986) , 10.1182/BLOOD.V68.6.1218.1218
Levent Yamenel, Mehmet Mas, Bilgin Comert, Ahmet Isik, Sezai Aydin, Nuket Mas, Salih Deveci, Mustafa Ozyurt, Ilker Tasci, Tahir Unal, The effect of activated protein C on experimental acute necrotizing pancreatitis Critical Care. ,vol. 9, pp. 191- ,(2005) , 10.1186/CC3485
François Fourrier, Recombinant human activated protein C in the treatment of severe sepsis: An evidence-based review Critical Care Medicine. ,vol. 32, pp. S534- S541 ,(2004) , 10.1097/01.CCM.0000145944.64532.53
R. S. Sohal, Heat stroke. An electron microscopic study of endothelial cell damage and disseminated intravascular coagulation Archives of Internal Medicine. ,vol. 122, pp. 43- 47 ,(1968) , 10.1001/ARCHINTE.122.1.43
M.-T. Lin, T.-Y. Kao, C.-F. Su, Stephen S.F. Hsu, Interleukin-1β production during the onset of heat stroke in rabbits Neuroscience Letters. ,vol. 174, pp. 17- 20 ,(1994) , 10.1016/0304-3940(94)90108-2
Chih-Ya Yang, Mao-Tsun Lin, Oxidative Stress in Rats With Heatstroke-Induced Cerebral Ischemia Stroke. ,vol. 33, pp. 790- 794 ,(2002) , 10.1161/HS0102.100208
Feisal A El-Kassimi, Shihab Al-Mashhadani, Anwar K. Abdullah, Jawaid Akhtar, Adult respiratory distress syndrome and disseminated intravascular coagulation complicating heat stroke. Chest. ,vol. 90, pp. 571- 574 ,(1986) , 10.1378/CHEST.90.4.571
Mao-Tsun Lin, Ching-Ping Chang, The neuropharmacological basis of heat intolerance and its treatment Journal of Thermal Biology. ,vol. 29, pp. 463- 469 ,(2004) , 10.1016/J.JTHERBIO.2004.08.015
Gordon R Bernard, E Wesley Ely, Theressa J Wright, Joseph Fraiz, Jerome E Stasek Jr, James A Russell, Irvin Mayers, Brian A Rosenfeld, Peter E Morris, S Betty Yan, Jeffery D Helterbrand, rhAPC Sepsis Study Group, Safety and dose relationship of recombinant human activated protein C for coagulopathy in severe sepsis. Critical Care Medicine. ,vol. 29, pp. 2051- 2059 ,(2001) , 10.1097/00003246-200111000-00003
ABDERREZAK BOUCHAMA, ADAM CAFEGE, EDWARD B. DEVOL, OSAMA LABDI, KHALID EL-ASSIL, MOHAMMED SERAJ, Ineffectiveness of dantrolene sodium in the treatment of heatstroke. Critical Care Medicine. ,vol. 19, pp. 176- 180 ,(1991) , 10.1097/00003246-199102000-00011