Endothelial nitric oxide synthase gene Glu298Asp polymorphism in patients with coronary artery disease.
作者： Heidar Tavilani , Hamid Zand , Mohsen Firoozrai , Saeedeh Salimi , Ahmad Mohebbi
关键词: Polymorphism (computer science) 、 Population 、 Odds ratio 、 Endocrinology 、 Medicine 、 Risk factor 、 Molecular biology 、 Internal medicine 、 Haplotype 、 Genotype frequency 、 Single-nucleotide polymorphism 、 Genotype
摘要: RESULTS: The genotype frequencies of Glu298Asp polymorphism for Glu/Glu, Glu/Asp, and Asp/Asp were 61.3%, 32.2%, 6.5%, respectively, in control subjects, 46.5%, 42.7%, 10.8% CAD patients, respectively. differed significantly between the two groups (P=.003). Asp alleles 32.2% 22.6% patients respectively; difference was statistically significant (P=.001; odds ratio=1.6). Plasma lipids, except HDL-C, also increased groups. CONCLUSION: These results suggest that is associated with NOS3 gene our population this an independent risk factor CAD.
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