Allometric Pharmacokinetic Scaling: Towards the Prediction of Human Oral Pharmacokinetics
作者： Meihua Rose Feng , Xiaochun Lou , Richard R. Brown , Athiwat Hutchaleelaha
关键词: Volume of distribution 、 Allometry 、 Scaling 、 Pharmacology toxicology 、 Pharmacology 、 Bioavailability 、 Unbound drug 、 Pharmacokinetics 、 Body weight 、 Chemistry
摘要: Purpose. To evaluate (1) allometric scaling of systemic clearance (CL)using unbound drug concentration, (2) the potential usage brainweight (BRW) correction in both CL and oralclearance (CL/F).
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