Model for receptor-controlled cytosolic calcium oscillations and for external influences on the signal pathway.

摘要: The external stimulation of many cells by a hormone, for example, often leads to an oscillating cytosolic calcium concentration. This periodic behavior is now designated the oscillator. A theoretical model presented that describes this on basis inositol(1,4,5)trisphosphate-induced oscillations. In contrast other models only single positive feedback loop taken into account obtain includes important innovations compared approaches. It contribution extracellular and its modification after cell. Furthermore, signal pathway oscillations described in more detail than models. enables investigations influence additional parameters like electromagnetic fields transduction pathway. calculations are based theory nonlinear self-sustained oscillators.